Official specs from Steam

The Binding of Isaac: Rebirth system requirements

Minimum and recommended PC specs as listed by the developer on Steam. Native macOS version available. Native Linux build available.

The Binding of Isaac: Rebirth release infoSteam page Check other games

Minimum

OSXP
ProcessorCore 2 Duo
Memory2 GB RAM
GraphicsDiscreet video card
Storage449 MB available space
Sound CardYes

Recommended

OS *Windows 8 / 7 / Vista / XP
Processor2.4 GHz Quad Core 2.0 (or higher)
Memory8 GB RAM
GraphicsIntel HD Graphics 4000 and higher, ATI Radeon HD-Series 4650 and higher, Nvidia GeForce 2xx-Series and up
Storage449 MB available space
Sound CardYes

macOS minimum

OS10.8
ProcessorCore 2 Duo
Memory2 GB RAM
GraphicsDiscreet video card
Storage449 MB available space
Sound CardYes

macOS recommended

OS10.9
Processor2.4 GHz Dual Core 2.0 (or higher)
Memory8 GB RAM
GraphicsIntel HD Graphics 4000 and higher, ATI Radeon HD-Series 4650 and higher, Nvidia GeForce 2xx-Series and up.
Storage449 MB available space
Sound CardYes

FAQ

What graphics card do I need for The Binding of Isaac: Rebirth?

Minimum: Discreet video card. Recommended: Intel HD Graphics 4000 and higher, ATI Radeon HD-Series 4650 and higher, Nvidia GeForce 2xx-Series and up.

How much RAM does The Binding of Isaac: Rebirth need?

The Binding of Isaac: Rebirth needs 2 GB RAM at minimum, 8 GB RAM recommended.

How big is The Binding of Isaac: Rebirth?

The Binding of Isaac: Rebirth requires 449 MB available space.

Does The Binding of Isaac: Rebirth run on Mac or Steam Deck/Linux?

Yes, there is a native macOS version. A native Linux build is available.